Main objective of our research group (LBCS) is to investigate chemical and biological macromolecular systems using spectroscopic, microscopic and computational methods. We use fluorescence based steady state and time resolved spectroscopy and microscopy techniques to understand interactions between key biomolecules such as proteins, DNA and RNA.
Our research objectives include;
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Characterization of the excited-state photophysical properties of molecules.
Fluorescence spectroscopy and structural dynamics of serum and milk proteins.
Biophysical analysis of protein-DNA/RNA interactions.
Structural and dynamics impact of epigenetic modifications on DNA.
Development of chemical tools for biomolecular imaging and biosensing applications.
Exploring the luminescence behavior of nanomaterials such as graphene oxides, carbon dots and nanocrystals.
Publications
Dineshbabu Takkella, Mayur Suryawanshi, Meghna Mani, Satheesh Ellipilli*, and Krishna Gavvala*
Carbazole-Rhodanine Conjugate Acts as an Effective Fluorescence Biomarker for Protein Structural Dynamics Studies
Int. J. Biol. Macromol., 2025, 323, 147156.
Dipanjan Mukherjee, Stefano Ciaco, Lara Martinez-Fernandez, Krishna Gavvala, Elisa Bombarda, Aurélie Bourdérioux, Dmytro Dziuba, Fabien Hanser, Nicolas Humbert, Aqib Javed, Marc Mousli, Pankhi Singh, Yitzhak Tor, Roberto Improta, Mattia Mori, Yves Mély*
Decoding the Base Flipping Mechanism of the SET- and RING-Associated (SRA) Domain of the Epigenetic UHRF1 Protein
Nucleic Acids Res., 2025, 53, gkaf909.
Sudhanshu Sharma, Jyoti Vishwakarma, Jacek Czub, Subrahmanyam Sappati*, and Krishna Gavvala*
Elucidation of the Synergistic Interaction Between Bilirubin and Casein Protein: An Integrated Spectroscopy and Computational Approach
Biomacromolecules, 2025, 26, 5298.
Thor van Heesch, Sudhanshu Sharma, Bert van Erp, Alberto Pérez de Alba Ortíz, Remus T Dame*, Jocelyne Vreede*, Krishna Gavvala*
Adaptation of DNA to Protein Binding Revealed by Spectroscopy and Molecular Simulation
J. Phys. Chem. B, 2025, 129, 5653.
Madushmita Hatimuria, Jyoti Vishwakarma, Sudhanshu Sharma, Krishna Gavvala, Ashok Pabbathi*
Natural Deep Eutectic Solvent Acts as an Activator of Laccase Enzyme
J. Mol. Liq., 2025, 434, 128022.
Madushmita Hatimuria, Jyoti Vishwakarma, Dineshbabu Takkella, C. Nikesh Chandran, Plabana Phukan, Krishna Gavvala*, Ashok Pabbathi*
Repurposing of Approved Drugs towards Nipah Virus Treatment: An In Silico Docking, Molecular Dynamics Simulation and a MM/GBSA Approach
In Silico Pharmacology, 2025, 13, 1.
Sudhanshu Sharma, Dineshbabu Takkella, Jyoti Vishwakarma, Krishna Gavvala*
Influence of Bovine Liver Catalase on Self-Assembled Structures of a Surface Active Ionic Liquid
Langmuir, 2025, 41, 10177.
Dineshbabu Takkella, Sudhanshu Sharma, Krishna Gavvala*
Coumarin 153, a Solvatochromic Fluorescent Probe, for Analyzing the Biodiesel Blends Derived from Various Feedstocks
Spectrochim. Acta. A., 2025, 330, 125755.
Dineshbabu Takkella, Sudhanshu Sharma, Jyoti Vishwakarma, Krishna Gavvala*
Bile Salt Induced Aggregation and Nanostructure Formation of β-Lactoglobulin in Gastrointestinal Environments
Food Hydrocoll., 2025, 162, 110944.
Jyoti Vishwakarma, Sudhanshu Sharma, Dineshbabu Takkella, Krishna Gavvala*
Unveiling Differential Interaction Pattern for Iminium and Alkanolamine Forms of Sanguinarine with β-Lactoglobulin Protein
Int. J. Biol. Macromol., 2024, 283, 137721.
Sudhanshu Sharma, Dineshbabu Takkella, Abhinav Srivastava, Jacek Czub, Subrahmanyam Sappati*, Krishna Gavvala*
Unraveling Energy Transfer and Fluorescence Quenching Dynamics in Biomolecular Complexes: A Comprehensive Study of Imiquimod-Rifampicin Interaction
Phys. Chem. Chem. Phys., 2024, 26, 26291.
Dineshbabu Takkella, Sudhanshu Sharma, Satyanarayana Samireddi*, Krishna Gavvala*
Probing Photoinduced Electron Transfer Events in Phenylferrocene-Corrole Dyad
Phys. Chem. Chem. Phys., 2024, 26, 21688.
Dineshbabu Takkella, Lara Martinez-Fernandez, Krishna Gavvala*
Solvent Effect on the Excited State Photophysics of Imiquimod: a DFT/TD-DFT and Spectroscopic Study
J. Photochem. Photobiol. A., 2024, 457, 115928.
Sudhanshu Sharma, Dineshbabu Takkella, Krishna Gavvala*
Probing Ionic Liquid Based Micellar Structures Using the Photophysical Properties of a Plant Alkaloid: Spectroscopy and Microscopy Based Approach
J. Mol. Liq., 2024, 401, 124632.
Jyoti Vishwakarma, Dineshbabu Takkella, Sudhanshu Sharma, Krishna Gavvala*
Modulation of Excimer Formation and Photostability of Avobenzone inside the Nanocavities of Cyclodextrins
J. Photochem. Photobiol. A., 2024, 449, 115411.
Dineshbabu Takkella, Sudhanshu Sharma, Jyoti Vishwakarma, Javier Cerezo, Lara Martinez-Fernandez, Krishna Gavvala*
Unveiling the Interaction Modes of Imiquimod with DNA: Biophysical and Computational Studies
J. Photochem. Photobiol. A., 2024, 447, 115190.
Sudhanshu Sharma, Dineshbabu Takkella, Jyoti Vishwakarma, Krishna Gavvala*
Spectroscopy and Dynamics of beta-Lactoglobulin Complexed with Rifampicin
J. Biomol. Struct. Dyn., 2023, 42, 13460.
Dineshbabu Takkella, Sudhanshu Sharma, Radoslaw Krzemieniecki, Ashok Pabbathi, Subrahmanyam Sappati, Krishna Gavvala*
Targeting Spike-ACE2 Interface of SARS-CoV-2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
ChemistrySelect, 2023, 8 (32), e202302687.
Madushmita Hatimuria, Joydeep Das, Krishna Gavvala, Soumabha Bag, Ashok Pabbathi*
Recent Advances in the use of Laccase Enzyme in Deep Eutectic Solvents
Sustain. Chem. Pharm., 2023, 33, 101148.
Madushmita Hatimuria, Plabana Phukan, Soumabha Bag, Jyotirmoy Ghosh, Krishna Gavvala, Ashok Pabbathi*, Joydeep Das*
Green Carbon Dots: Applications in Development of Electrochemical Sensors, Assessment of Toxicity as Well as Anticancer Properties
Catalysts, 2023, 13 (3), 537.
Sudhanshu Sharma, Dineshbabu Takkella, Pintu Kumar, Krishna Gavvala*
Spectroscopic Analysis to Identify the Binding Site for Rifampicin on Bovine Serum Albumin
Spectrochim. Acta. A., 2022, 283, 121721.
Dineshbabu Takkella, Sudhanshu Sharma, Lara Martinez-Fernandez*, Krishna Gavvala*
Excited-State Dynamics of Imiquimod in Aqueous Solutions
J. Photochem. Photobiol. A., 2022, 431, 113998.
Stefano Ciaco, Krishna Gavvala, Vanille Greiner, Viola Mazzoleni, Pascal Didier, Marc Ruff, Lara Martinez-Fernandez, Roberto Improta, Yves Mély*
Thienoguanosine Brightness in DNA Duplexes is Governed by the localization of its ππ* Excitation in the Lowest Energy Absorption Band
Methods Appl. Fluoresc., 2022, 10, 035003.
Complete List of Publications
Dineshbabu Takkella, Mayur Suryawanshi, Meghna Mani, Satheesh Ellipilli*, and Krishna Gavvala*
Carbazole-Rhodanine Conjugate Acts as an Effective Fluorescence Biomarker for Protein Structural Dynamics Studies
Int. J. Biol. Macromol., 2025, 323, 147156.
Dipanjan Mukherjee, Stefano Ciaco, Lara Martinez-Fernandez, Krishna Gavvala, Elisa Bombarda, Aurélie Bourdérioux, Dmytro Dziuba, Fabien Hanser, Nicolas Humbert, Aqib Javed, Marc Mousli, Pankhi Singh, Yitzhak Tor, Roberto Improta, Mattia Mori, Yves Mély*
Decoding the Base Flipping Mechanism of the SET- and RING-Associated (SRA) Domain of the Epigenetic UHRF1 Protein
Nucleic Acids Res., 2025, 53, gkaf909.
Sudhanshu Sharma, Jyoti Vishwakarma, Jacek Czub, Subrahmanyam Sappati*, and Krishna Gavvala*
Elucidation of the Synergistic Interaction Between Bilirubin and Casein Protein: An Integrated Spectroscopy and Computational Approach
Biomacromolecules, 2025, 26, 5298.
Thor van Heesch, Sudhanshu Sharma, Bert van Erp, Alberto Pérez de Alba Ortíz, Remus T Dame*, Jocelyne Vreede*, Krishna Gavvala*
Adaptation of DNA to Protein Binding Revealed by Spectroscopy and Molecular Simulation
J. Phys. Chem. B, 2025, 129, 5653.
Madushmita Hatimuria, Jyoti Vishwakarma, Sudhanshu Sharma, Krishna Gavvala, Ashok Pabbathi*
Natural Deep Eutectic Solvent Acts as an Activator of Laccase Enzyme
J. Mol. Liq., 2025, 434, 128022.
Madushmita Hatimuria, Jyoti Vishwakarma, Dineshbabu Takkella, C. Nikesh Chandran, Plabana Phukan, Krishna Gavvala*, Ashok Pabbathi*
Repurposing of Approved Drugs towards Nipah Virus Treatment: An In Silico Docking, Molecular Dynamics Simulation and a MM/GBSA Approach
In Silico Pharmacology, 2025, 13, 1.
Sudhanshu Sharma, Dineshbabu Takkella, Jyoti Vishwakarma, Krishna Gavvala*
Influence of Bovine Liver Catalase on Self-Assembled Structures of a Surface Active Ionic Liquid
Langmuir, 2025, 41, 10177.
Dineshbabu Takkella, Sudhanshu Sharma, Krishna Gavvala*
Coumarin 153, a Solvatochromic Fluorescent Probe, for Analyzing the Biodiesel Blends Derived from Various Feedstocks
Spectrochim. Acta. A., 2025, 330, 125755.
Dineshbabu Takkella, Sudhanshu Sharma, Jyoti Vishwakarma, Krishna Gavvala*
Bile Salt Induced Aggregation and Nanostructure Formation of β-Lactoglobulin in Gastrointestinal Environments
Food Hydrocoll., 2025, 162, 110944.
Jyoti Vishwakarma, Sudhanshu Sharma, Dineshbabu Takkella, Krishna Gavvala*
Unveiling Differential Interaction Pattern for Iminium and Alkanolamine Forms of Sanguinarine with β-Lactoglobulin Protein
Int. J. Biol. Macromol., 2024, 283, 137721.
Sudhanshu Sharma, Dineshbabu Takkella, Abhinav Srivastava, Jacek Czub, Subrahmanyam Sappati*, Krishna Gavvala*
Unraveling Energy Transfer and Fluorescence Quenching Dynamics in Biomolecular Complexes: A Comprehensive Study of Imiquimod-Rifampicin Interaction
Phys. Chem. Chem. Phys., 2024, 26, 26291.
Dineshbabu Takkella, Sudhanshu Sharma, Satyanarayana Samireddi*, Krishna Gavvala*
Probing Photoinduced Electron Transfer Events in Phenylferrocene-Corrole Dyad
Phys. Chem. Chem. Phys., 2024, 26, 21688.
Dineshbabu Takkella, Lara Martinez-Fernandez, Krishna Gavvala*
Solvent Effect on the Excited State Photophysics of Imiquimod: a DFT/TD-DFT and Spectroscopic Study
J. Photochem. Photobiol. A., 2024, 457, 115928.
Sudhanshu Sharma, Dineshbabu Takkella, Krishna Gavvala*
Probing Ionic Liquid Based Micellar Structures Using the Photophysical Properties of a Plant Alkaloid: Spectroscopy and Microscopy Based Approach
J. Mol. Liq., 2024, 401, 124632.
Jyoti Vishwakarma, Dineshbabu Takkella, Sudhanshu Sharma, Krishna Gavvala*
Modulation of Excimer Formation and Photostability of Avobenzone inside the Nanocavities of Cyclodextrins
J. Photochem. Photobiol. A., 2024, 449, 115411.
Dineshbabu Takkella, Sudhanshu Sharma, Jyoti Vishwakarma, Javier Cerezo, Lara Martinez-Fernandez, Krishna Gavvala*
Unveiling the Interaction Modes of Imiquimod with DNA: Biophysical and Computational Studies
J. Photochem. Photobiol. A., 2024, 447, 115190.
Sudhanshu Sharma, Dineshbabu Takkella, Jyoti Vishwakarma, Krishna Gavvala*
Spectroscopy and Dynamics of beta-Lactoglobulin Complexed with Rifampicin
J. Biomol. Struct. Dyn., 2023, 42, 13460.
Dineshbabu Takkella, Sudhanshu Sharma, Radoslaw Krzemieniecki, Ashok Pabbathi, Subrahmanyam Sappati, Krishna Gavvala*
Targeting Spike-ACE2 Interface of SARS-CoV-2 and its Omicron Variant: A Comparative Screening of Potential Inhibitors for Existing and Anticipating Variants Using Molecular Modelling Approach
ChemistrySelect, 2023, 8 (32), e202302687.
Madushmita Hatimuria, Joydeep Das, Krishna Gavvala, Soumabha Bag, Ashok Pabbathi*
Recent Advances in the use of Laccase Enzyme in Deep Eutectic Solvents
Sustain. Chem. Pharm., 2023, 33, 101148.
Madushmita Hatimuria, Plabana Phukan, Soumabha Bag, Jyotirmoy Ghosh, Krishna Gavvala, Ashok Pabbathi*, Joydeep Das*
Green Carbon Dots: Applications in Development of Electrochemical Sensors, Assessment of Toxicity as Well as Anticancer Properties
Catalysts, 2023, 13 (3), 537.
Sudhanshu Sharma, Dineshbabu Takkella, Pintu Kumar, Krishna Gavvala*
Spectroscopic Analysis to Identify the Binding Site for Rifampicin on Bovine Serum Albumin
Spectrochim. Acta. A., 2022, 283, 121721.
Dineshbabu Takkella, Sudhanshu Sharma, Lara Martinez-Fernandez*, Krishna Gavvala*
Excited-State Dynamics of Imiquimod in Aqueous Solutions
J. Photochem. Photobiol. A., 2022, 431, 113998.
Stefano Ciaco, Krishna Gavvala, Vanille Greiner, Viola Mazzoleni, Pascal Didier, Marc Ruff, Lara Martinez-Fernandez, Roberto Improta, Yves Mély*
Thienoguanosine Brightness in DNA Duplexes is Governed by the localization of its ππ* Excitation in the Lowest Energy Absorption Band
Methods Appl. Fluoresc., 2022, 10, 035003.
Complete List of Publications